The STRONG STAR Multidisciplinary PTSD Research Consortium
Abstract
We propose two experiments addressing the effectiveness of SSRIs for the treatment of PTSD in OEF/OIF veterans with combat-related trauma. First we will collaborate with Dr. Young who is conducting a Fluoxetine vs. placebo comparison for the treatment of PTSD among OEF/OIF active-duty personal stationed at Fort Hood after their return from deployment in the Middle East. For this study, we will add to the ongoing clinical trial, assessment of drinking behavior and four other measures necessary to derive patients' alcohol-related subtype. Second, we will conduct a prospective study comparing the effectiveness of Sertraline vs. Placebo to treat PTSD in OEF/OIF veterans who have a PTSD + Alcohol Dependence dual diagnosis and are seeking treatment within the VA. For Both studies we hypothesize that alcohol-related subtypes can be derived from amongst the subject population which will predict the outcomes of treatment with the SSRIs. Also, both studies will collect DNA for the assessment of genetic polymorphisms pertinent to the prediction of treatment outcome.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2009
- Accession Number
- ADA515405
Entities
People
- John D. Roache
Organizations
- University of Texas Health Science Center at San Antonio