Preclinical Mouse Models of Neurofibromatosis
Abstract
This report describes the past four years of research performed by a Consortium of investigators who were continuously funded by this Program since 1999 to develop, characterize, and utilize strains of mice that accurately model tumors found in persons with NF1 and NF2. This Consortium has generated many novel models of NF1 and NF2-associated tumors and has exploited these strains to investigate biologic and preclinical questions. The investigators have collaborated closely and have extensively shared expertise and reagents with each other and with NF researchers around the world. These mouse strains developed through this effort are a cornerstone of NF research and are instrumental to an effort by the Children's Tumor Foundation to organize and support a preclinical network for testing therapeutics that might benefit persons with NF1 and NF2 disease.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2009
- Accession Number
- ADA516646
Entities
People
- Kevin Shannon
Organizations
- University of California, San Francisco