Killing Breast Cancer Cells Through Activation of the Apoptosome

Abstract

Cells die in response to chemotherapeutic agents by activating pathway. This pathway leads to activation of proteases known of cytochrome c from mitochodria. Once released, cytochrome known as Apaf-1, which oligomerizes and activates caspase cancer cells have apoptosomes which are hypersensitive to develop cytoplasmic variants of cytochrome c and/or small to activate the apoptosome in breast cancer cells.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2009
Accession Number
ADA516650

Entities

People

  • Sally Kornbluth

Organizations

  • Duke University

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Apoptosomes
  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Cytochromes
  • Department Of Defense
  • Fluorescence
  • Molecules
  • Neoplasms
  • Phosphorylation
  • Proteins
  • Schematic Diagrams
  • Small Molecules
  • Tyrosine

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.