Biocompatibility and Toxicological Effects of Doped, Functionalized and Pure Carbon Nanotubes
Abstract
We wrote a review article for Advanced Materials together with Dr. Hussain's group about the toxicity evaluation for safe use of nanomaterials. This paper has been highlighted by the journal as of the of the most downloaded papers in two months (see report). From the experimental standpoint, we synthesized different types of carbon nanotubes (CNTs) multiwalled carbon nanotubes (MWNTs), nitrogen-doped (CNx) MWNTs, phosphorus- and nitrogen-doped (CNxPy) MWNTs, ethanol -based (carobonyl, carboxyl functionalized) CNT (COx-MWNTs) and B-doped (CBx) MWNTs. We also prepared and evaluated different suspensions for biological applications of CNTs. We found that H2S04, acetic acid, HNO3V/H2S04 mixtures and chloroform were suitable for suspending the different types of tubes. Ag nanopartides were chemically anchored on the surface of MWNTs. COxMWNTs and CNxMWNTs. Cellular function and immune response were evaluated to determine biocompatibility of the synthesized nanomaterials on the human keratinocyte cell line(HaCaT). Cellular assays revealed toxicity after 24h. However, full cellular recovery was observed at 48h. Therefore AG nanoparticles (if anchored to CNTs) have ability to interact with cells and preserve cellular function.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 25, 2009
- Accession Number
- ADA517182
Entities
People
- Mauricio Terrones
Organizations
- Instituto Potosino de Investigación Científica y Tecnológica