Targeting siRNA Missiles to Her2+ Breast Cancer

Abstract

The most significant findings here are that HerPBK10 protects siRNA from serum nuclease-mediated degradation, T7 transcribed siRNA is more cytotoxic than synthetic siRNA when delivered to HER2+ breast cancer cells by HerPBK10 in vitro, HerPBK10 directs siRNA-mediated cytotoxicity to HER2+ but not HER2- cells in vitro, the HerPBK10 carrier preferentially accumulates in HER2+ tumors in vivo when delivered systemically (intravenously), and cytotoxicity is associated with siRNA-mediated induction of IFN-alpha.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2009
Accession Number
ADA517257

Entities

People

  • Lali K Medina-Kauwe

Organizations

  • Cedars-Sinai Medical Center

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Blood
  • Breast Cancer
  • Carrier Proteins
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Cytokines
  • Diseases And Disorders
  • Gene Therapy
  • Immune Serums
  • Neoplasms
  • Proteins
  • Skin Diseases
  • Targeting
  • Tissues

Fields of Study

  • Biology

Readers

  • Oncology (Cancer Research).