Structure and Function of the Splice Variants of TMPRSS2-ERG, a Prevalent Genomic Alteration in Prostate Cancer
Abstract
Characterization of major TMPRSS2-ERG splice variants in prostate cancer specimens for the first time provides information on the full length protein coding sequences of TMPRSS2-ERG fusion transcripts which is urgently needed in developing more precise bio-marker and therapeutic strategies. Unexpected discovery on predominance of type II splice variants e.g., TMPRSS2-ERG8 and identification of novel splice variants: TMPRSS2-EPC1 and TMPRSS2-EPC2 represents the unique outcome of this grant effort focusing on unbiased evaluation of fusion transcripts in prostate cancer. Definition of the relative abundance of the TMPRSS2-ERG splice variants in prostate cancer provide novel information with respect to type II TMPRSS2-ERG transcripts and prognostic value of measuring the ratio of type II and type I transcripts. These data suggest that over all biologic effects of TMPRSS2-ERG fusion may be a reflection of potential interaction of these splice variants.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2009
- Accession Number
- ADA517260
Entities
People
- Shiv Srivastava
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine