The Influence of Physical Forces on Progenitor Cell Migration, Proliferation and Differentiation in Fracture Repair

Abstract

The goal of this program is to investigate the influence of controlled mechanical stimulation on the behavior of progenitor cells in an effort to develop strategies to significantly enhance the rate and quality of fracture repair in long bone. Progress in the program has been excellent. The results to date demonstrate the application of load increases the callus volume, bone mineral density and biomechanical properties. More importantly, the data demonstrates a substantial independence on the time of load application. Load stimulation can positively influence fracture repair when applied at 10 or 24 days after fracture, while early application (during granulation tissue formation) may be detrimental to tissue regeneration. We also demonstrated that introduced progenator cells play an indirect role on the repair and identified a variety of factors that may be associated with repair cell recruitment. The results are beginning to support new strategies for enhancing fracture repair

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2008
Accession Number
ADA517339

Entities

People

  • Kurt D. Hankenson
  • Michael Kilbourn
  • Steven A. Goldstein

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Bone And Bones
  • Bone Fractures
  • Bone Regeneration
  • Cartilage
  • Cell Movement
  • Cells
  • Connective Tissue
  • Connective Tissue Cells
  • Mechanical Properties
  • Osteogenesis
  • Peptide Growth Factors
  • Stem Cells
  • Surgery
  • Tissues

Readers

  • Logistics and Supply Chain Management.
  • Materials Science (Mechanical Engineering).
  • Oncology (Cancer Research).