PCBs Alter Dopamine Mediated Function in Aging Workers

Abstract

The major hypothesis is that prior occupational exposure to polychlorinated biphenyls (PCBs) results in decrements in the number of dopamine (DA) terminals in the basal ganglia determined by Beta-CIT SPECT imaging. Data collection is complete (a comprehensive questionnaire, examinations and SPECT imaging). PCBs and thyroid hormones have been measured in serum and bone lead has been determined. Results, obtained using -CIT SPECT imaging, demonstrate a significant negative relationship between current serum PCB concentrations and decreases in the density of -CIT binding only in women. Serum PCB concentrations have decreased 10-fold from peak values during occupational PCB use but remain elevated (two-fold) compared to a similar-aged non-occupationally exposed population. Estimating PCB half lives using analysis of both current and archived serum samples revealed significantly longer half lives for PCB congeners of occupational origin in women compared to men. Data analysis and manuscript preparation continues for neurological and neuropsychological endpoints.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2010
Accession Number
ADA517349

Entities

People

  • Richard F. Seegal

Tags

DTIC Thesaurus Topics

  • Brain
  • Chemical Synthesis
  • Chemistry
  • Data Analysis
  • Data Science
  • Environmental Health
  • Fish
  • Hydrocarbons
  • Information Science
  • Neurology
  • Neurons
  • Parkinson'S Disease
  • Polychlorinated Biphenyls
  • Public Health
  • Regression Analysis
  • Statistical Analysis
  • Surveys

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