The Role of Protein Kinase D (PKD) Signaling in Breast Cancer Cell Migration and Invasion

Abstract

The goal of my project as outlined in the original application is to analyze the role of Protein Kinase D (PKD) in breast cancer cell motility, the phenotype critical for metastasis. The work I have conducted includes the demonstration that loss of PKD in a number of highly metastatic breast cancer cell lines results in a migration defect. I have also discovered a potential isoform specificity of PKD in the control of breast cancer cell motility.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2009
Accession Number
ADA517509

Entities

People

  • Claudine Christoforides

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Movement
  • Cells
  • Genetics
  • Kinases
  • Mass Spectrometry
  • Metastasis
  • Microscopy
  • Migration
  • Neoplasms
  • Phenotypes
  • Phosphorylation
  • Prostate Cancer

Fields of Study

  • Biology

Readers

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