The Isolation and Characterization of Human Prostate Cancer Stem Cells

Abstract

The overall objective of this proposal is to develop a durable cure for lethal prostate cancer through the elucidation of the role of cancer stem cells in the pathogenesis of the disease. During the past year, we have made the following significant findings: i) CD44, a putative prostate cancer stem cell marker, is localized to neuroendocrine cells in prostate cancer, ii) employing a specific feeder layer, it is possible to model prostate cancer initiation in vitro and iii) classic tissue recombination utilizing primary human prostate cancer cells, to the recapitulate the human disease, does not work. We are currently working to optimize and validate our in vitro model of prostate cancer initiation to facilitate cancer stem cell discovery as well as drug targeting.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2009
Accession Number
ADA518099

Entities

People

  • Ganesh S. Palapattu

Organizations

  • University of Rochester

Tags

DTIC Thesaurus Topics

  • Antigens
  • Biology
  • Carcinoma
  • Cell Line
  • Cells
  • Chemistry
  • Department Of Defense
  • Diseases And Disorders
  • Endocrine Cells
  • Epithelial Cells
  • Health Services
  • Medical Personnel
  • Neoplasms
  • Prostate Cancer
  • Regression Analysis
  • Stem Cells
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology