Cerebrovascular Injury in Blast Loading

Abstract

The central hypothesis of this project is that the function of the cerebral vasculature is impaired in response to primary blast loading. A shock tube is being utilized to study overpressure alteration of cerebral blood flow and disruption of the blood-brain barrier in the living rat, along with change of passive and active response of isolated rat cerebral vessels. Key accomplishments during the first year of this award include construction of a shock tube, development of a computational model to simulate blast production using a shock tube, and modification of a vessel testing system to accommodate rat cerebral vessels and to allow fluid circulation with temperature and pH control.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2010
Accession Number
ADA518880

Entities

People

  • Kenneth L. Monson

Organizations

  • University of Utah

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Arteries
  • Blast
  • Blast Waves
  • Blood
  • Blood Flow
  • Blood Vessels
  • Blood-Brain Barrier
  • Brain
  • Brain Injuries
  • Central Nervous System
  • Measurement
  • Nervous System
  • Overpressure
  • Pressure Distribution
  • Shock Tubes
  • Simulations
  • Tubes

Fields of Study

  • Psychology

Readers

  • Cardiovascular Physiology
  • Explosive Engineering.
  • Software Engineering