Oxidative Stress, DNA Repair and Prostate Cancer Risk
Abstract
Oxidative stress, which results from an imbalance between ROS and antioxidant capacities, can cause a wide range of direct or indirect DNA damage. There are extensive DNA repair systems that can correct DNA damage caused by ROS before cell replication and mutation fixation. Although oxidative stress appears to be important in the etiology of prostate cancer, so far there is no study to comprehensively investigate the association between DRC of oxidative DNA damage as a phenotype and prostate cancer risk. We hypothesize that DRC of oxidative DNA damage as a phenotype may modify prostate cancer risk. So far, the study has recruited 156 cases and 132 controls. The proposed molecular analysis has begun for all three specific aims.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2009
- Accession Number
- ADA518882
Entities
People
- Hua Zhao
Organizations
- Health Research, Incorporated