PSMA-Targeted Nano-Conjugates as Dual-Modality (MRI/PET) Imaging Probes for the Non-Invasive Detection of Prostate Cancer
Abstract
The goal of this project is to develop dual modality imaging probes for the detection of prostate cancer by doping radioisotopes to iron oxide nanoparticles, so that the sensitivity and specificity of prostate cancer diagnosis could be significantly improved. During the funding period, a facile approach was developed to prepare gamma- or positron emitting nuclides incorporated SPIO nanoparticles (NUSPIONs) for dual modality imaging of prostate cancer. In this three-month extension, we successfully developed the logistics of importing 74As/GeO2 targets from Europe and developed a standardized operation protocol for the isotope separation and 74AsI3 preparation. Using 74AsI3, we have applied our developed methodology to synthesize 74As incorporated detxtran-coated iron oxide nanoparticles (~ 20 nm) and performed PET-CT and MRI evaluation in a PC-3 tumor mouse model. The PET/MRI dual modality imaging results clearly demonstrated the practicality of the methodology conceived and developed in this project for non-invasive detection of prostate cancer. Further research is warranted to move this project forward.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2010
- Accession Number
- ADA519262
Entities
People
- Xiankai Sun
Organizations
- University of Texas at Dallas