Human Neural Cell-Based Biosensor

Abstract

Carbohydrates corresponding to PhaL, VVA, DBA, LTL and PNA lectin binding are up regulated upon differentiation of hESCs. In particular, VVA, DBA, LTL and PNA lectin binding increases in hNPCs but not in hMPCs. This suggests that these carbohydrates might be specific for function of hNPCs and could be used for enrichment of hNPCs from a mixed population of cells. In future work VVA and PNA lectins will be used to isolate a pure population of HNPCs and used for developing a neural progenitor cell based biosensor.

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Document Details

Document Type
Technical Report
Publication Date
Apr 26, 2010
Accession Number
ADA519388

Entities

People

  • Jamie Chilton
  • Steven L. Stice

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Biosensors
  • Carbohydrates
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Department Of Defense
  • Electronic Mail
  • Genetic Engineering
  • Glycoproteins
  • Low Density
  • Membrane Proteins
  • Military Research
  • Proteins
  • Stem Cells
  • Synapses
  • Transcription Factors

Fields of Study

  • Biology
  • Chemistry

Readers

  • Microwave Engineering.
  • Molecular Biology and Genetics
  • Molecular Genetics

Technology Areas

  • Biotechnology