Calcium Homeostatasis and Mitochondrial Dysfunction in Dopaminergic Neurons of the Substantia Nigra

Abstract

Key Research Accomplishments: -the discovery that calcium entry through L-type channels during normal pacemaking elevates the sensitivity of SNc dopaminergic neurons to toxins; -the discovery that L-type calcium channels participate in but are not necessary for pacemaking; -the discovery that serum concentration of the dihydropyridine isradipine required to achieve protection of SNc dopaminergic neurons against toxins in animal models is similar to that achieved in humans by FDA approved doses; -the discovery that calcium entry through L-type channels during pacemaking elevates mitochondrial oxidant stress and leads to the engagement of a DJ-1-dependent oxidant defense system involving uncoupling proteins.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2010
Accession Number
ADA519458

Entities

People

  • D. James Surmeier

Organizations

  • Northwestern University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Brain
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemistry
  • Endoplasmic Reticulum
  • Health Services
  • Movement Disorders
  • Neurodegeneration
  • Neurons
  • Neurosciences
  • Parkinson'S Disease
  • Rodents

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Molecular and Cellular Biochemistry
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.