Dietary Influences on Alpha-Methylacyl-CoA Racemase (AMACR) Expression in the Prostate

Abstract

Alpha Methyl Acyl CoA Racemase (AMACR), a peroxisomal and mitochondrial enzyme, is up regulated in majority of prostate cancers (PCa). This enzyme is involved in the breakdown of phytanic & pristanic acids, which are derived primarily through the ingestion of dairy and red meat products. There are no studies done so far that have examined the relationship of this enzyme with red meat and dairy intake and therefore PCa risk. The current research focuses on examining the relationships between AMACR expression in the prostate and phytanic/pristanic acid levels in the blood and prostate. So far, 26 patients with Pca have been recruited in the study. Research staff has been trained to obtain dietary information as well as process tissue and blood samples from participants. Protocols for processing biological samples have been established. Preliminary optimization of laboratory assays including assays for quantifying AMACR using automated image analysis tools have been developed.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2009
Accession Number
ADA519467

Entities

People

  • Margaret E. Wright

Organizations

  • University of Illinois at Chicago

Tags

DTIC Thesaurus Topics

  • Cells
  • Chemical Synthesis
  • Chemistry
  • Gene Expression
  • Health Services
  • Kidneys
  • Medical Personnel
  • Neoplasms
  • Prostate Cancer

Readers

  • Gender and Food Studies
  • Prostate Cancer Biology.