Test for Chemical Induction of Chromosome Aberrations in Cultured Chinese Hamster Ovary (CHO) Cells With and Without Metabolic Activation. Test Article: Dimethylamine-2-2ethyl azide (DMAZ)
Abstract
Dimethylamine-2-2ethyl azide (DMAZ, 99.3% pure) was tested for its potentials to induce chromosome aberrations in cultured Chinese Hamster Ovary (CHO) cells with and without metabolic activation according to OECD TG 473 in compliance with Good Laboratory Practice. DMAZ was evaluated at concentrations of 10, 50, 100, 500, 1000, 2500, and 5000 microg/mL in both with and without activation and was found negative for clastogenic potential. A confirmatory chromosome aberration assay was performed without activation also showed negative.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 26, 2008
- Accession Number
- ADA519553
Entities
People
- Jian Song