The Influence of Physical Forces on Progenitor Cell Migration, Proliferation and Differentiation in Fracture Repair

Abstract

The goal of this program is to investigate the influence of controlled mechanical stimulation on the behavior of progenitor cells in an effort to develop strategies to significantly enhance the rate and quality of fracture repair in long bone. Progress in the program has been excellent. The results to date demonstrate the application of load increases the callus volume, bone mineral density and biomechanical properties. Early results also show that the The goal of this program is to investigate the influence of controlled mechanical stimulation on the behavior of progenitor cells in an effort to applied load may increase migration of systemically delivered progenitor cells to the repair site, but their role in repair may be more related to up regulating the repair, and not participation as differentiated repair cells. The results demonstrate the promise of load stimulation for enhancing fracture repair.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2007
Accession Number
ADA519722

Entities

People

  • Kurt D. Hankenson
  • Michael Kilbourn
  • Steven A. Goldstein

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Biomedical Research
  • Bone Fractures
  • Bone Marrow
  • Bone Regeneration
  • Bones
  • Cell Movement
  • Cells
  • Department Of Defense
  • Experimental Design
  • Growth Factors
  • Mechanical Properties
  • Migration
  • Orthopedics
  • Osteogenesis
  • Stem Cells
  • Tissues

Readers

  • Molecular Biology and Genetics
  • Systems Analysis and Design
  • Trauma Surgery or Emergency Medicine.