Early Assessment of Breast Cancer Therapy Response Using Photoacoustic Molecular Imaging
Abstract
The purpose of this grant is to build cancer-specific contrast agents for photoacoustic imaging, using which one could estimate the change in molecular expression of various breast-cancer-specific proteins undergoing chemotherapy treatment. We've made significant progress towards obtaining this goal: 1) we created the first-ever photoacoustic imaging agent (which is based on carbon nanotube nanoparticle) and showed it can specifically target tumors in tumor-bearing mice (paper published in Nature Nanotechnology); 2) We created 2 additional molecular imaging agents for photoacoustic imaging which exhibit 300-times higher sensitivity and for the first allow imaging photoacoustic molecular probes at sub-nanomolar concentrations (paper submitted to Nano Letters). We've shown that such sensitivity improvement results in the ability to image smaller tumors. Beyond higher sensitivity, the 3 imaging agents developed in this grant thus far have different optical spectra. We used this fact and have shown the ability to simultaneously image these agents (multiplexing). This ability is particularly powerful and important for this grant as we plan to progress to characterizing the response to chemotherapy of multiple cancer-specific proteins in the same tumor simultaneously.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2010
- Accession Number
- ADA520562
Entities
People
- Adam De Lazerda
Organizations
- Stanford University