A Novel Hand-Held Optical Imager with Real-Time Co-registration Facilities toward Diagnostic Mammography
Abstract
Hand-held based optical imaging devices using near-infrared (NIR) light are currently developed toward clinical translation of the technology. However, none of the NIR devices developed to date have attempted 3D tomography since they are not able to coregister the image to the tissue geometry. The objective for the work described herein is the clinical translation of a hand-held optical imager with automated coregistration facilities toward 3D tomography. Studies were performed in vivo with normal human subjects to demonstrate fast (near real-time) 2D fluorescence imaging for target detection prior to 3D tomography. The results showed that 0.23 cm3 and 0.45 cu cm fluorescent targets placed behind the breast tissue were detected through ~2.5 cm deep tissue. Parallely, studies were performed on phantoms composed of minced chicken breast and 1% Liposyn solution to demonstrate coregistered imaging in vitro. The results showed that the 3D tracking system was able to track the position of the probe in real-time and accurately coregister the image to the geometry of the object. Additionally, deeper targets can be detected upon summation of multiple coregistered images. These results demonstrate the potential of the device to perform 3D tomographic imaging in human subjects via coregistered imaging on complex breast geometries.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2010
- Accession Number
- ADA520829
Entities
People
- Sarah Erickson
Organizations
- Florida International University