Perfluoro-N-Butyl Iodide (PFBI): A 13-Week Nose-Only Inhalation Toxicity Study In Rats With A 4-Week Recovery Period
Abstract
Perfluoro-n-butyl iodide (PFBI) is an environmentally acceptable (i.e., zero ozone depletion potential) replacement solvent for cleaning oxygen systems. A 13-week study was conducted in order to develop a health risk assessment. Fischer 344 rats (15 males & 10 females per group) were exposed for 6 hr/day to 0 (Air Control), 500, 1500 or 5000 ppm of PFBI for 5 days/week for 13 consecutive weeks (at least 65 exposures) followed by a 4-week recovery period. Clinical observations, body weights, clinical pathology, thyroid function, organ weights and histopathology were conducted at the end of the treatment period for up to 10 animals/sex/group. Remaining animals (5 males/group) were held for a 4-week recovery period. The target tissue following 13 weeks of daily inhalation exposure of rats to PFBI was the thyroid. The findings consisted of a minimal thyroid follicular cell hypertrophy occasionally accompanied by hyperplasia but without an increase in thyroid weight in the 500, 1500 and 5000 ppm males; only one 5000 ppm female had similar histopathological thyroid changes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2006
- Accession Number
- ADA521478
Entities
People
- Darol E. Dodd
- David R. Mattie
- Gary M. Hoffman
- Peter J. John
Organizations
- ALION SCIENCE & TECHNOLOGY CORP