Role of the Chemokine MCP-1 in Sensitization of PKC-Mediated Apoptosis in Prostate Cancer Cells

Abstract

Our studies identified a novel paradigm by which PKC activation drives apoptotic responses in prostate cancer cells, which involves the autocrine release of TNFalpha TRAIL, and MCP-1 (CCL2). MCP-1(CCL2) sensitizes the death effect of other cytokines through a PKC-dependent pathway. Phorbol esters control the expression and release of these cytokines/chemokines from prostate cancer cells. These effects are primarily mediated by PKCalpha and PKCdelta. On the other hand, PKCepsilon opposes these effects, and confer protection for apoptosis. Our studies also identified an important role for androgens in the control of the secretion of cytokines/chemokines from prostate cancer cells.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2010
Accession Number
ADA521768

Entities

People

  • Marcelo G Kazanietz

Organizations

  • University of Pennsylvania

Tags

DTIC Thesaurus Topics

  • Androgens
  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Culture Techniques
  • Department Of Defense
  • Epithelial Cells
  • Fibroblasts
  • Neoplasms
  • Peptide Growth Factors
  • Programmed Cell Death
  • Prostate
  • Prostate Cancer
  • Proteins

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Cellular and Molecular Pathways of Apoptosis.
  • Prostate Cancer Biology.