Prostate Specific or Enriched Genes as Composite Biomarkers for Prostate Cancer

Abstract

Purpose and scope of research: To evaluate prostate specific genes such as WDR19, NDRG1, TAGLN2 as diagnosis and prognosis markers for prostate cancers. Major findings: (1) We have determined that WDR19, NDRG1 are not as good a marker as PSA for prostate cancer stratification. (2) We developed a mouse antibody for a putative prostate biomarker TAGLN2. (3) We have generated a novel panel of more than 10 prostate-specific proteins that expressed highly in prostate tissues. We will develop multiplexed antibody assays as well as mass spectrometry based targeted proteomics approach for validating these candidate biomarkers in patient serum samples.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2010
Accession Number
ADA521769

Entities

People

  • Leroy Hood

Organizations

  • Institute for Systems Biology

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Assays
  • Biological Markers
  • Biomedical Research
  • Cell Physiological Processes
  • Composite Materials
  • Computational Biology
  • Mass Spectrometry
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Proteomics
  • Spectrometry
  • Systems Biology
  • Tissues

Fields of Study

  • Medicine
  • Physics

Readers

  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology