A Blast Model of Traumatic Brain Injury in Swine
Abstract
The purpose of this study is to develop a survival model of blast-induced traumatic brain injury (BI-TBI) in swine. Two air guns have been constructed, each having different lengths, air chamber volumes and barrel diameters. Using a digital ballistics chronometer the air velocity was measured over a series of firings at different controlled pressures in the air chambers. Calibration curves from both air guns show linear and reproducible results through a range of firing pressures. Behavioral/learning/memory testing has been developed which will detect cognitive and behavioral changes for up to 2 months following BI-TBI. To date swine have received BI-TBI with the air guns of two different sizes and were recovered for 7 days post injury. BI-TBI with the larger gun caused initial pain requiring analgesia and reduced weight gain compared to injury generated with the smaller gun. Brains will be examined for molecular markers of injury. Histology and immunocytochemistry will evaluate cytoarchitecture, degenerating neurons and morphology. When completed this swine model BI-TBI will provide a needed tool for use in developing treatment and rehabilitation of traumatic head injuries as well as improvements in military protective body armor.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2009
- Accession Number
- ADA521809
Entities
People
- Samuel S. Panter
Organizations
- Northern California Institute for Research and Education