Canonical Wnt Signaling as a Specific Marker of Normal and Tumorigenic Mammary Stem Cells

Abstract

We have determined that the Wnt/B-catenin signaling pathway is active within a small subset of cells within the mammary gland. This small subset is entirely contained within the previously identified population that has the ability to repopulate a cleared mammary fat pad. Thus, activation of canonical Wnt signaling may be a very specific marker for mammary stem cells and be a target for transformation that results in the formation of aggressive mammary tumors.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2010
Accession Number
ADA523180

Entities

People

  • Bart O. Williams

Tags

DTIC Thesaurus Topics

  • Biological Staining And Labeling
  • Biomedical Research
  • Breast Cancer
  • Cells
  • Epithelial Cells
  • Gene Expression
  • Glands
  • Immune System
  • Lymph Nodes
  • Mammary Glands
  • Medical Personnel
  • Neoplasms
  • Stem Cells
  • Tissues
  • Transplantation

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology