Lymph Node Melanosis in a Patient With Metastatic Melanoma of Unknown Primary

Abstract

Tumoral or nodular melanosis in the skin is considered a variation of completely regressed melanoma, presenting clinically as a suspicious pigmented papule or nodule. Microscopically, the lesion consists of a nodular accumulation of heavily pigmented melanophages in the dermis, staining positive for immunohistochemical markers of histiocytic lineage (CD68) and negative for those of melanocytic lineage (S100, HMB-45, Melan-A). This process is rarely described in lymph nodes. We present a report of a patient with melanosis involving multiple lymph nodes of an axillary dissection, done for metastatic melanoma with an unknown primary, and discuss possible prognostic and treatment factors.n

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2009
Accession Number
ADA523423

Entities

People

  • Patrick Malafronte
  • Timothy Sorrells

Organizations

  • Walter Reed National Military Medical Center

Tags

DTIC Thesaurus Topics

  • Cells
  • Diseases And Disorders
  • Giant Cells
  • Lymph Nodes
  • Lymphatic System
  • Macrophages
  • Medical Personnel
  • Melanoma
  • Neoplasms
  • Pigmentation Disorders
  • Positron Emission Tomography
  • Positron Emissions
  • Skin Cancer
  • Soft Tissues
  • Tomography
  • X-Ray Computed Tomography

Fields of Study

  • Medicine

Readers

  • Molecular and Cellular Biology
  • Oncology and Biomarker-Based Cancer Detection.
  • Toxicology/Environmental Toxicology