The Role of the DNA Damage Response in Breast Cancer

Abstract

Using a novel mouse model to introduce oncogenes to murine somatic mammary epithelial cells, I have found that acute expression of the ErbB2 oncogene can induce a robust DNA damage response in premalignant lesions, similar to what has been observed in clinical breast samples. This response results in p53 stabilization, apoptosis, and senescence and requires intact ATM function. Furthermore, during sporadic ErbB2 tumor evolution, p53 stabilization and apoptosis are lost, indicating these are critical tumor suppressive mechanisms in curtailing ErbB2 tumorigenesis. However, senescence remains in ErbB2 tumors, suggesting that it may not be a critical barrier to tumorigenesis.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2010
Accession Number
ADA524937

Entities

People

  • Jay P. Reddy

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Breast Cancer
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Epithelial Cells
  • Genetics
  • Growth Factors
  • Health Services
  • Neoplasms
  • Oncology
  • Proteins
  • Skin Diseases
  • Stem Cells

Readers

  • Molecular Biology and Genetics