Molecular Mechanisms Underlying Individual Differences in Response to Stress in a Previously Validated Animal Model of PTSD
Abstract
Purpose: To make use of an existing rat model for PTSD where individual differences in long-term behavioral responses to the scent of a predator results in extreme responses for 25% of animals thought to be analogous to "PTSD," while 25% of the animals show stress resistance. That the extreme behavioral effects can be blocked by cortisol administration prior to stress appears similar to observations in trauma survivors of the prophylactic effects of cortisol. The animal model has not been used to identify CNS gene expression patterns or other biomarkers underpinning biological mechanisms of individual differences in reactivity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2009
- Accession Number
- ADA525484
Entities
People
- Rachel Yehuda