PSA Prodrug-Based Multimodality Agents for Imaging Metastatic Prostate Cancer

Abstract

The purpose of this work is to prepare and test a series of PSA binding prodrugs which contain both a fluorescent and radioactive group which can bind to enzymaticly active PSA in the vicinity of the tumor where the polar peptide portion is cleaved producing a lipophilic cleavage product which intercalates in the cell membrane of the tumor and nearly cells. In this period we made progress in the synthesis of iodinated and radioiodinated fluorescent PSA prodrugs and PSA cleavage products. In particular we were able to introduce the acid labile tributyl tin moiety needed to incorporate the radioiodine into the molecule towards the end of the synthetic route.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2010
Accession Number
ADA525527

Entities

People

  • Ronnie C. Mease

Organizations

  • Johns Hopkins Hospital

Tags

DTIC Thesaurus Topics

  • Acetic Acid
  • Ammonium Compounds
  • Biomedical Research
  • Cell Membrane
  • Cells
  • Cells (Biology)
  • Cellular Structures
  • Chemical Compounds
  • Department Of Defense
  • Information Operations
  • Membranes
  • Molecules
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Tributyl Tin

Readers

  • Medical Imaging.
  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).