Role of Fibroblast Growth Factor Binding Protein-1 in Mammary Development and Tumorigenesis

Abstract

Fibroblast growth factors (FGFs) are vital modulators of development as well as angiogenesis. They play a large role in vascular formation, body axis patterning, cell migration and organ branching. The scientific community is still piecing together the role that distinct FGFs play due to the complexity of the FGF network, which involves 22 distinct members that signal through 4 receptors to activate 3 major signaling pathways.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2009
Accession Number
ADA525608

Entities

People

  • Krissa Gibby

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Epithelial Cells
  • Fibroblasts
  • Growth Factors
  • Mammary Glands
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Polymerase Chain Reaction
  • Proteins

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular Biology and Genetics