New Strategy for Prostate Cancer Prevention Based on Selenium Suppression of Androgen Receptor Signaling

Abstract

In this project, we investigated the potential of targeting the androgen receptor and the 5(alpha)-reductase simultaneously in prostate cancer prevention. We report that this combined androgen receptor blockade approach produced a synergistic effect on tumor growth inhibition by in vitro and in vivo. We have also identified that methylseleninic acid (MSA) activates FOXO1 and FOXO1 activation plays an important role in mediating apoptosis induction and androgen receptor suppression by MSA. In summary, the research support by this grant suggests a novel and effective approach for managing early stage prostate cancer and contributes to a better understanding of the anticancer effects of MSA.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2010
Accession Number
ADA525643

Entities

People

  • Haitao Zhang

Organizations

  • Tulane University of Louisiana

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Apoptosis
  • Body Weight
  • Cell Physiological Processes
  • Cells
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Culture Techniques
  • Enzyme Inhibitors
  • Gene Expression
  • Hormones
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Vitamin E

Fields of Study

  • Biology

Readers

  • Prostate Cancer Biology.