Protection of Humans against Malaria by Immunization with Radiation-Attenuated Plasmodium falciparum Sporozoites
Abstract
During 1989-1999, 11 volunteers were immunized by the bites of 1001-2927 irradiated mosquitoes harboring infectious sporozoites of Plasmodium falciparum (Pf) strain NF54 or clone 3D7/NF54. Ten volunteers were first challenged by the bites of Pf-infected mosquitoes 2-9 weeks after the last immunization, and all were protected. A volunteer challenged 10 weeks after the last immunization was not protected. Five previously protected volunteers were rechallenged 23-42 weeks after a secondary immunization, and 4 were protected. Two volunteers were protected when rechallenged with a heterologous Pf strain (7G8). In total, there was protection in 24 of 26 challenges. These results expand published findings demonstrating that immunization by exposure to thousands of mosquitoes carrying radiation-attenuated Pf sporozoites is safe and well tolerated and elicits strain-transcendent protective immunity that persists for at least 42 weeks.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 15, 2002
- Accession Number
- ADA526278
Entities
People
- Chris Paul
- Denise L. Doolan
- Imogene Schneider
- John Sacci
- Lucy M. Goh
- Megan Dowler
- Patricia De La Vega
- Stephen L. Hoffman
- Thomas C. Luke
- Thong P. Le
Organizations
- Naval Medical Research Center