Role of Hsp90 in Androgen-Refractory Prostate Cancer

Abstract

A major challenge in prostate cancer research is to develop novel therapies that can delay or prevent the progression of androgen-sensitive prostate cancer to androgen-independence. Androgen receptor (AR) is often overexpressed and plays an essential role in androgen-refractory prostate tumors. Our preliminary studies suggest that heat shock protein 90 (Hsp90) is required for androgen-independent AR nuclear localization in androgen-refractory prostate cancer cells. This project tested our research hypothesis that Hsp90 plays a critical role in ligand-independent AR nuclear localization, an essential step leading to androgen-refractory prostate cancer. During the funding period, we showed that Hsp90 deacetylation by HDAC6 is a critical step involved in castration resistance of prostate cancer cells.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2010
Accession Number
ADA526578

Entities

People

  • Zhou Wang

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Androgen Receptors
  • Biomedical Research
  • Biotechnology
  • Castration
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Diseases And Disorders
  • Enzyme Inhibitors
  • Genetic Code
  • Hormones
  • Indicator Dyes
  • Prostate Cancer
  • Proteins
  • Resistance
  • Tissues

Readers

  • Breast cancer cell signaling and growth regulation.
  • Prostate Cancer Biology.