Dietary Influences on Alpha-Methylacyl-CoA Racemase (AMACR) Expression in the Prostate
Abstract
Alpha Methyl Acyl CoA Racemase (AMACR), a peroxisomal and mitochondrial enzyme, is up regulated in majority of prostate cancers (PCa). This enzyme is involved in the breakdown of phytanic & pristanic acids, which are derived primarily through the ingestion of dairy and red meat products. There are no studies done so far that have examined the relationship of this enzyme with red meat and dairy intake and therefore PCa risk. The current research focuses on examining the relationships between AMACR expression in the prostate and phytanic/pristanic acid levels in the blood and prostate. So far, 30 patients with Pca have been recruited in the study at UIC / JBVAMC. Research staff has been trained to obtain dietary information and process tissue and blood samples from participants. Protocols for processing biological samples have been established. Optimization of phytanic / pristanic acid assays has been completed and assays for quantifying AMACR using automated image analysis tools have been developed. Data and biological samples from 40 additional subjects are expected from a newly established collaboration with the Henry Ford Health System.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2010
- Accession Number
- ADA526671
Entities
People
- Margaret E. Wright
Organizations
- University of Chicago