Noninvasive Subharmonic Pressure Estimation for Monitoring Breast Cancer Response to Neoadjuvant Threapy

Abstract

Neoadjuvant chemotherapy is currently the standard of care for locally advanced breast cancer (LABC). Monitoring tumor response is advantageous for patients. This project aims at establishing noninvasive monitoring of neoadjuvant chemotherapy in the breast using subharmonic aided pressure estimation (SHAPE) to estimate the interstitial fluid pressure (IFP) in LABC. To date, in vitro experiments with 2 ultrasound contrast agents (Definity andSonazoid) have showed an inverse linear relationship between the change in subharmonic amplitude and hydrostatic pressure (r2 = 0.76?0.91, p < 0.01) over the pressure range associated with breast tumors (0 ? 47 mmHg). These results indicate that the use of SHAPE for noninvasive evaluation of the IFP in breast lesions is feasible with both Definity and Sonazoid. Moreover, software for analyzing RF data from a Sonix RP scanner to produce SHAPE pressure estimates has been successfully developed. However, difficulty in aligning the in vitro setup has delayed the project by approximately 6 months

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2009
Accession Number
ADA527632

Entities

People

  • Flemming Forsberg

Organizations

  • Thomas Jefferson University

Tags

DTIC Thesaurus Topics

  • Amplitude
  • Breast Cancer
  • Chemotherapy
  • Contrast
  • Diseases And Disorders
  • Elastic Properties
  • Frequency
  • Hydrostatic Pressure
  • Linear Regression Analysis
  • Measurement
  • Monitoring
  • Neoplasms
  • Pressure Measurement
  • Regression Analysis
  • Statistical Analysis
  • Therapy
  • United States

Readers

  • Cardiovascular Physiology
  • Medical Imaging.