Transrectal Near-Infrared Optical Tomography for Prostate Imaging
Abstract
Purpose 1: to evaluate whether trans-rectal spectral optical tomography of total hemoglobin concentration [HbT] can be used to detect prostate cancer development. Findings: Spectral detection at 785nm and 830nm enabled quantitation of [HbT]. Canine TVT cells were injected into the right lobe of a dog's prostate gland. Longitudinal imaging assessment of the post-injection prostate was performed by trans-rectal US-coupled spectra optical tomography over a 45-day duration. The average [HbT] in an area of TVT concentrated tumor foci changed from 120 microMeters to 375 microMeters over the 45-day duration. Transrectal US-coupled spectral optical tomography seems capable of detecting the development and lateral involvement of prostate cancer earlier than by transrectal US alone. Purpose 2: to evaluate the challenges of the optical heterogeneities of prostate imposed on in vivo imaging of prostate cancer. Findings: a comprehensive review of the published data on optical properties of canine and human prostate is conducted. Purpose 3: to develop a theory of photon diffusion that accounts for the cylinder-shape applicator used in prostate imaging. Findings: a unified theory of steady-state photon diffusion for using cylinder-shape applicator to image internally or externally is developed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2010
- Accession Number
- ADA527667
Entities
People
- Daqing Piao
Organizations
- Oklahoma State University–Stillwater