Engineered Protein Polymers

Abstract

We have developed protein block polymers as well as homopolymers comprised cartilage oligomeric matrix protein coiled coil (C) and elastin (E). Three fusion - EC, CE and ECE - have been biosynthesized and characterized for their physicochemical properties in addition to the homopolymers. Depending on the orientation and the number of blocks, we discover that the secondary structure and supramolecular assemblies vary. In general, the block polymers assembled into particles that presented different mechanical properties. The C homopolymer, however, is able to assemble into fibers in a metal dependent fashion. Finally, we demonstrate that we can control the thermoresponsive behavior of the block polymer through the control of the E domain length.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 31, 2010
Accession Number
ADA528318

Entities

People

  • Jin K Montclare

Organizations

  • New York University

Tags

Communities of Interest

  • Energy and Power Technologies

DTIC Thesaurus Topics

  • Assembly
  • Biological Sciences
  • Block Polymers
  • Cartilage
  • Chemical Synthesis
  • Chemistry
  • Elastic Properties
  • Low Temperature
  • Mass Spectrometry
  • Mechanical Properties
  • Metallic Nanoparticles
  • Molecular Biology
  • Molecules
  • Particle Size
  • Particles
  • Polymers
  • Small Molecules

Readers

  • Molecular Genetics
  • Molecular and Cellular Biochemistry
  • Polymer Science and Technology