Studies on Metabolism of 1,4-Dioxane

Abstract

1,4-Dioxane was added as a stabilizer to the banned degreasing solvent 1,1,1,-trichloroethane, and still has uses in the manufacture of small arms ammunition. Due to past and current uses, dioxane is of concern to the Army with regard to both pollution prevention and remediation of past use. The US Environmental Protection Agency classifies dioxane as a probable human carcinogen based upon animal studies. One of the most important data gaps with respect to dioxane is its potential mode of action in causing cancer. Past work has identified two potential metabolities of dioxane, but definitive studies on the relationship of these possible metabolites to one another in living systems and their possible relation to carcinogenesis have remained unanswered. This report provides information supporting 2-hydroxyethoxyacetic acid (HEAA) as being the principal metabolite, and provides the first quantitative data on the chemical equilibrium between HEAA and the other potential metabolite-dioxanone. Suggestions for future research are included.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2010
Accession Number
ADA528633

Entities

People

  • William S. Eck

Organizations

  • United States Army Public Health Command

Tags

DTIC Thesaurus Topics

  • Ammunition
  • Cancer
  • Chemical Synthesis
  • Chemistry
  • Digestive System Processes
  • Environmental Protection
  • Laboratory Animals
  • Mass Spectrometry
  • Medical Personnel
  • Neoplasms
  • Nose
  • Organic Chemistry
  • Organic Compounds
  • Rodents
  • Small Arms
  • Small Arms Ammunition
  • Wounds And Injuries

Fields of Study

  • Chemistry

Readers

  • Aerial Unmanned Vehicle Swarm Micro Periodontal Dentistry.
  • Environmental Engineering.
  • Toxicology/Environmental Toxicology