Peptides for Specific Intracellular Delivery and Targeting of Nanoparticles: Implications for Developing Nanoparticle-Mediated Drug Delivery

Abstract

The use of peptides to mediate the delivery and uptake of nanoparticle (NP) materials by mammalian cells has grown significantly over the past 10 years. This area of research has important implications for the development of new therapeutic materials and for the emerging field of NP-mediated drug delivery. In this review, we highlight recent advances in the delivery of various NPs by some of the more commonly employed cellular delivery peptides and discuss important related factors such as NP-peptide bioconjugation, uptake efficiency, intracellular fate and toxicity. We also highlight various demonstrations of therapeutic applications of NP-peptide conjugates where appropriate. The paper concludes with a brief forward-looking perspective discussing what can be expected as this field develops in the coming years.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2010
Accession Number
ADA529089

Entities

People

  • Christopher E. Bradburne
  • Igor L. Medintz
  • James B. Delehanty
  • Jason E. Bongard
  • Kelly Boeneman
  • Kelly Robertson

Organizations

  • United States Naval Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Blood
  • Brain
  • Cell Line
  • Cell Membrane
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Epithelial Cells
  • Materials Laboratories
  • Materials Science
  • Materials Testing
  • Metallic Nanoparticles
  • Nanotechnology
  • Peptides
  • Stem Cells
  • Tumor Cell Line

Fields of Study

  • Medicine

Readers

  • Molecular and Cellular Biochemistry
  • Nanocomposite Materials Science
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech