Rapid Formation of Acrylated Microstructures by Microwave-Induced Thermal Crosslinking

Abstract

We present a rapid and highly efficient method to form microstructure of poly(ethylene glycol) (PEG)-based acrylates by microwave-induced thermal crosslinking. PEG-based polymeric microstructures such as polymer microarrays and microwells were fabricated on 3-(trimethoxysilyl)propyl methacrylate (TMSPMA)-coated glass slides that were placed on top of a silicon wafer. In comparison to ultraviolet (UV) irradiation curing, microwave-induced thermal crosslinking could be completed within 10s without thermal degradation or oxygen inhibition in the presence of ambient oxygen. Furthermore, the activation of surviving free radical impurities by microwave-induced heating enabled crosslinking even without an exogenous radical initiator. This approach can be beneficial for fabricating various PEG-based microstructures for high-throughput screening assays, cellbased biosensors, and biomedical microdevices.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2010
Accession Number
ADA532135

Entities

People

  • Ali Khademhosseini
  • Bong G. Chung
  • Jae H. Park
  • Seung H. Lee
  • Won G. Lee

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical

DTIC Thesaurus Topics

  • Acrylates
  • Alkenes
  • Biomedical Engineering
  • Biosensors
  • Chemical Synthesis
  • Chemistry
  • Engineering
  • Ethylene Glycol
  • Ethylenes
  • Explosives Initiators
  • Free Radicals
  • Glycols
  • Impurities
  • Inhibition
  • Methacrylates
  • Microstructure
  • Microwave Ovens

Fields of Study

  • Materials science

Readers

  • Aerosol Science/Aerosol Physics
  • Molecular Genetics
  • Polymer Science and Technology

Technology Areas

  • Biotechnology