Regulation and Action of SKP2 in Cell and Tumor Models: Mechanisms Underlying Aggressive Growth in Basel-Like Breast Cancer

Abstract

The objective of this research is to further our understanding of the molecular mechanisms underlying the aggressive growth of estrogen receptor (ER)-negative, basal-like breast tumors. My goal is to determine if SKP2 is a viable new therapeutic target to specifically treat patients who have tumors that are independent of ER signaling. The most significant result was the establishment of a TMX2-28 cell line that has been stably transfected with a SKP2-shRNA construct. This cell line will be instrumental in elucidating the role that SKP2 plays in breast cancer progression.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2010
Accession Number
ADA533255

Entities

People

  • Katerina Fagan-solis

Organizations

  • University of Massachusetts Amherst

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Biological Sciences
  • Biology
  • Biomedical Research
  • Biotechnology
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Department Of Defense
  • Gene Expression
  • Medical Personnel
  • Neoplasms
  • Proteins
  • Tumor Cell Line

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Naval Architecture and Marine Engineering.
  • Oncology (Cancer Research).