Genome-wide Analysis of Germline CNPs and SNPs in Prostate Cancer
Abstract
Prostate cancer (PCa) is the leading cancer among men in the United States, and is a disease with strong genetic susceptibility. The genetic susceptibility is due to the inheritance of altered germline DNA sequences, either in the form of point mutations such as single nucleotide polymorphisms (SNPs), or deletions/gains of a string of nucleotides such as copy number polymorphisms (CNPs). Most current genetic studies focus only on the role of SNPs in genetic susceptibility. In contrast, few studies have explored the role of deletions/gains in cancer predisposition, due to limited methods. In fact, germline deletions/gains are common in the human genome and may have a significant impact on gene products because they can involve an entire gene or a significant portion of a gene. They may play a more important role in hereditary PCa (HPC), a type of PCa that is likely due to germline changes in major genes. We have successfully completed the study by identifying common germline CNVs in hereditary prostate cancer (HPC) patients; and identifying a candidate germline CNV that is associated with hereditary prostate cancer risk among Ashkenazi Jews. We also tested the association of these germline CNVs with prostate cancer risk in all HPC family members.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2010
- Accession Number
- ADA534038
Entities
People
- Jianfeng Xu
Organizations
- Wake Forest University