Biomarkers of Fatigue: Ranking Mental Fatigue Susceptibility

Abstract

This is the mental fatigue susceptibility ranking portion of a study seeking to determine metabolic biomarkers for resistance to fatigue. A total of 23 paid subjects completed a fatigue protocol involving informed consent, medical screening, Tuesday and Wednesday evening training on cognitive tasks, providing five urine samples (beginning with a Friday morning baseline), refresher training, and an experimental session (with six, four hour long blocks) starting Friday evening. Subjects showed the expected declines in performance during the 36-hour, 15-minute period of sleep deprivation without caffeine. The simple change from baseline results on the Psychomotor Vigilance Task (PVT) is recommended as the primary classifier for mental fatigue susceptibility. The next part of the study will use nuclear magnetic resonance (NMR) spectroscopy, liquid chromatography (LC), and mass spectrometry (MS) of the urine samples to determine if biomarkers are indicators of mental fatigue susceptibility.

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Document Details

Document Type
Technical Report
Publication Date
Dec 10, 2010
Accession Number
ADA534096

Entities

People

  • Donald L. Harville
  • Justin M. Billot
  • Monica S. Herrera
  • Nicholas Delraso
  • Scott R. Chaiken

Organizations

  • Air Force Research Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Research Laboratories
  • Attrition
  • Beverages
  • Biological Markers
  • Data Analysis
  • Factor Analysis
  • Information Science
  • Institutional Review Board
  • Liquid Chromatography
  • Magnetic Resonance
  • Mass Spectrometry
  • Military Operations
  • Military Research
  • Motor Skills
  • Nuclear Magnetic Resonance
  • Resonance

Readers

  • Circadian Sleep-Wake Regulation and Chronobiology
  • Clinical Trial Research.
  • Instructional Design and Training Evaluation.