Distinct Types of T-cell Help for the Induction of a Humoral Immune Response to Streptococcus pneumoniae
Abstract
Studies have indicated that purified soluble polysaccharide antigens can elicit T cell-independent Ig responses in vivo, although these responses can be modulated by T cells in a noncognate manner. Relatively little is known, however, concerning the parameters that regulate polysaccharide-specific, as well as protein-specific, Ig isotype responses to an intact extracellular bacterium. Using the murine in vivo humoral response to intact Streptococcus pneumoniae as a model it can be shown that CD4+T-cell receptor alpha beta+T cells deliver help for both polysaccharide- and protein-specific Ig responses. However, these responses differ fundamentally in their mechanism of action.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2001
- Accession Number
- ADA534237
Entities
People
- Abdul Q. Khan
- Clifford M Snapper
- James J. Mond
- Jesus Colino
- Piotr Zelazowski
- William C. Gause
- Yi Shen
- Zheng-qi Wu
Organizations
- Uniformed Services University of the Health Sciences