Reducing Prostate Cancer Disparities through Behavioral and Biologic Epidemiologic Approaches
Abstract
PURPOSE:This study seeks to define the optimal dose of vitamin D supplementation in Blacks needed for future intervention efforts in the prevention of prostate cancer. SCOPE: Study subjects were randomized to placebo, 1000IU, 2000IU, or 4000IU of vitamin D3 per day to determine the minimum dose of vitamin D needed to achieve an optimal level. After 3 months of supplementation, plasma levels of 25(OH)D and PSA are determined and compared to baseline levels. We also assessed of 25(OH)D and PSA 6 months. The goal was to enroll 320 participants, including 100 men, into the study. A 3-phase eligibility and consent process was use. 1. Only people who were AA, English-speaking, and 30-80 years old were approached to participate in the study; 2. Basic non-clinical eligibility criteria were assessed;3. Primary care were contacted to assess clinical eligibility. To encourage retention, a case-manager approach was implemented which included biweekly calls and monthly pill bottle exchange visits. UP-TO-DATE FINDINGS: We consented 572 individuals and exceeded our recruitment goals with 329 participants enrolled in the study, including 107 men. Retention for the 3- and 6-month assessment was 90.54% and 89.13%, respectively. The supplementation and follow-up periods for this study has recently completed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2010
- Accession Number
- ADA534809
Entities
People
- Bettina F. Drake
Organizations
- Washington University in St. Louis