Noninvasive Detection of Lactate as a Biomarker of Response Using Spectral-Selective Multiple Quantum Editing Sequence (SS-SelMQC)

Abstract

This application focuses on enhancing cancer care by developing non-invasive techniques to determine better biomarkers to improve diagnostic specificity and decrease the number of negative biopsies, and also as markers of response with novel targeted agents such as Trastuzumab and Bevacizumab. Until now, we have constructed radiofrequency coils suitable for studying breast tumors implanted on foot and mammary fat pad, optimized SelMQC, SS-SelMQC, and SEE-SelMQC sequences for lactate/choline detection from whole tumors as well as localized 2D slices with high-resolution using phantoms and part of these methods are tested with in vivo MCa-7 tumors.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2010
Accession Number
ADA534912

Entities

People

  • Sunitha B. Thakur

Organizations

  • Memorial Sloan Kettering Cancer Center

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Biological Markers
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Chemical Shifts
  • Department Of Defense
  • Detection
  • Diameters
  • High Resolution
  • Magnetic Resonance
  • Measurement
  • Neoplasms
  • New York
  • Resonance
  • Sequences
  • Water

Readers

  • Medical Imaging.
  • Oncology (Cancer Research).

Technology Areas

  • Quantum Computing