Miniature and Molecularly Specific Optical Screening Technologies for Breast Cancer

Abstract

The goal of this proposal is to harness the power of light to create ?miniature and molecularly specific optical technologies? for breast cancer diagnosis and detection. The miniature technologies will leverage on millimeter scale silicon detectors and LEDs to make compact devices that can be used in a practical clinical setting for breast cancer detection. The features that will be exploited for optical detection/diagnosis of breast cancer will include the physiological, structural and molecular alterations that accompany the transformation of a cell from a normal to malignant state. This proposal also focuses on using contrast agents, specifically aminolevulinic acid (ALA) induced protoporphyrin IX (PpIX) and NBDG, for the molecular detection of breast cancer.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2010
Accession Number
ADA535162

Entities

People

  • Nimmi Ramanujam

Organizations

  • Duke University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Aminolevulinic Acid
  • Breast Cancer
  • Capillary Tubes
  • Cell Line
  • Cell Physiological Processes
  • Contrast
  • Detection
  • Detectors
  • Geometry
  • Light Sources
  • Measurement
  • Neoplasms
  • Optical Detection
  • Optical Properties
  • Optics
  • Oxygenation
  • Spectroscopy

Fields of Study

  • Physics

Readers

  • Molecular and genetic basis of cancer.
  • Oncology
  • Optical Physics and Photonics.