Intraoperative Molecular Imaging for Rapid Assessment of Tumor Margins
Abstract
The objective of this research is to develop methods for rapid detection of tumor margins during breast cancer surgery using targeted fluorescence-labeled tracers. Three dimensional modeling of tumors in excised tissue has been accomplished and the introduction of spectral resolution in the imaging strategy shows promise for quantifying tumor depth in the tissue. A spectrally-resolved prototype imaging system was developed and initial studies demonstrated the potential to determine the depth of embedded tumor fragments in the excise tissue or surgical cavity. Pilot animal data with the Licor IRDye800CW-2DG imaging agent in excised MDA231 tumors showed poor specificity and tumor penetration, though further studies with more specific probes are ongoing. Finally, ROC analysis quantified the improvement in diagnostic performance of diffuse tomography when accurate MRI information is encoded in the imaging algorithm.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2010
- Accession Number
- ADA535168
Entities
People
- Scott C. Davis
Organizations
- Dartmouth College