Genetically Modified Porcine Skin Grafts for Treatment of Severe Burn Injuries
Abstract
The most significant research findings in this time period include the fact that we have demonstrated that our genetically-modified pigskin grafts will perform as well human cadaveric allogeneic skin grafts as a temporary biologic cover for severe burn injuries for war-fighters. Our xenoskin transplants from pig to baboons have confirmed that our genetically-modified pigskin grafts last as long as baboon allograft skin, are not damaged by freezing, and are effective at treating full-thickness skin injuries typically seen in burn injuries sustained in combat. In addition, a short course of immunosuppression may enhance the efficacy of these grafts. Finally, our in vitro analysis has suggested a number of immunologic targets that may improve this approach in particular and xenotransplantation in general.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2010
- Accession Number
- ADA535275
Entities
People
- Curtis L. Cetrulo, Jr
- David H. Sachs
Organizations
- Massachusetts General Hospital