Novel Targeting Approach for Breast Cancer Gene Therapy
Abstract
Impaired balance between pro-apoptotic and anti-apoptotic molecules is common in cancer cells, including breast cancer, and it plays an important role in tumor initiation and progression. Proapoptotic gene therapy aims at enhancing the capacity of tumor cells to undergo apoptosis and renders the tumors sensitive to classical anticancer drugs and radiotherapy. We developed a novel therapeutic strategy that combines both targeted gene (p53) delivery using sigma-receptor ligand-conjugated PAMAM dendrimers, followed by chemotherapy using doxorubicin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2010
- Accession Number
- ADA535363
Entities
People
- Srinath Palakurthi
Organizations
- Texas A&M University